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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Role of Estrogens on Some Cognition-Related Aspects

Author(s): F. Jimenez-Trejo, J. Suarez, J. Espinosa-Raya and O. Picazo

Volume 11, Issue 13, 2011

Page: [1742 - 1749] Pages: 8

DOI: 10.2174/156802611796117658

Price: $65


Two of the most studied brain areas related with learning and memory are prefrontal cortex and hippocampus. However, serious inconsistencies arise when these regions are analyzed in relation to the role of estrogens on cognitive deterioration. Some of these contradictions are reviewed in the context of the recently proposed critical period hypothesis, which takes into account the frame-time after cessation of ovarian function. Other factors related with cognition and influenced by estrogens include their role on; a) cholinergic central transmission, b) spinogenesis and synaptogenesis at hippocampus, and c) classical genomic and rapid non genomic effects. Understanding the cellular and molecular basis of these phenomena is vital for designing novel therapeutic actions applicable to human health and disease.

Keywords: DENDRITIC SPINE DENSITY, Alzheimer's disease, genomic and rapid non genomic effects, spinogenesis and synaptogenesis, cholinergic central transmission, ovarian function, cognitive deterioration, hippocampus, prefrontal cortex, dendritic morphology, neurotransmitters, Estrogens

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