Abstract
Very premature birth frequently results in chronic respiratory morbidity, particularly if complicated by the development of chronic lung disease, bronchopulmonary dysplasia (BPD). Affected infants may remain oxygen dependent for many months and require hospital readmission in the first two years after birth. Troublesome, recurrent respiratory symptoms requiring treatment are common. The worst affected may remain symptomatic with evidence of airways obstruction even as adults. Infant who are born prematurely and develop BPD are at increased risk of severe respiratory syncytial virus (RSV) infection. RSV infection in prematurely born infants is associated with excess chronic respiratory morbidity, as evidenced by greater frequency of respiratory symptoms, lung function abnormalities and healthcare utilisation. There is some evidence to suggest that prematurely born infants, as those born at term, may be predisposed to symptomatic RSV lower respiratory tract infections by pre-morbid abnormal lung function. Longitudinal studies assessing lung function before and after RSV infection are required to determine whether RSV infection does alter the course of chronic lung disease in prematurely born infants.
Keywords: Respiratory syncytial virus, chronic lung disease, premature infants, birth, morbidity, bronchopulmonary dysplasia, respiratory symptoms, infants, bronchiolitis
Current Respiratory Medicine Reviews
Title: Does RSV Infection Alter the Course of Chronic Lung Disease in Prematurely Born Infants?
Volume: 7 Issue: 3
Author(s): Simon Drysdale and Anne Greenough
Affiliation:
Keywords: Respiratory syncytial virus, chronic lung disease, premature infants, birth, morbidity, bronchopulmonary dysplasia, respiratory symptoms, infants, bronchiolitis
Abstract: Very premature birth frequently results in chronic respiratory morbidity, particularly if complicated by the development of chronic lung disease, bronchopulmonary dysplasia (BPD). Affected infants may remain oxygen dependent for many months and require hospital readmission in the first two years after birth. Troublesome, recurrent respiratory symptoms requiring treatment are common. The worst affected may remain symptomatic with evidence of airways obstruction even as adults. Infant who are born prematurely and develop BPD are at increased risk of severe respiratory syncytial virus (RSV) infection. RSV infection in prematurely born infants is associated with excess chronic respiratory morbidity, as evidenced by greater frequency of respiratory symptoms, lung function abnormalities and healthcare utilisation. There is some evidence to suggest that prematurely born infants, as those born at term, may be predisposed to symptomatic RSV lower respiratory tract infections by pre-morbid abnormal lung function. Longitudinal studies assessing lung function before and after RSV infection are required to determine whether RSV infection does alter the course of chronic lung disease in prematurely born infants.
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Cite this article as:
Drysdale Simon and Greenough Anne, Does RSV Infection Alter the Course of Chronic Lung Disease in Prematurely Born Infants?, Current Respiratory Medicine Reviews 2011; 7 (3) . https://dx.doi.org/10.2174/157339811795589441
DOI https://dx.doi.org/10.2174/157339811795589441 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
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