Novel Coumarin and 4H-Chromene Derivatives Containing 4,5- Dihydropyrazole Moiety: Synthesis and Antibacterial Activity

Title: Novel Coumarin and 4H-Chromene Derivatives Containing 4,5- Dihydropyrazole Moiety: Synthesis and Antibacterial Activity

Volume: 8 Issue: 6

Author(s): Qian-Zhu Li, Xiao-Yan Nie and Jie Liang

Affiliation:

Keywords: Coumarin, Dihydropyrazole, 4H-chromene, Antibacterial activity, 4,5-Dihydropyrazole, Moiety, Multidrug resistance, benzopyridone, B. subtilis ATCC 6633, E. coli ATCC 35218, P. aeruginosa

Abstract: Seven novel 6-(1-acetyl-3-(6-substituted-2-oxo-2H-chromen-3-yl)-4,5-dihydro-1H-pyrazol-5-yl)-2-amino-4- substituted-4H-chromene-3-carbonitrile derivatives were synthesized and characterized by 1H NMR and 13C NMR. All of the compounds have been screened for their antibacterial activity. The results show that compounds 4d and 4g displayed significant activity with MIC of 1.562 μg/mL against B. subtilis ATCC 6633 and 1.562, 3.125 μg/mL against S. aureus ATCC 6538.

Cite this article as:

Li Qian-Zhu, Nie Xiao-Yan and Liang Jie, Novel Coumarin and 4H-Chromene Derivatives Containing 4,5- Dihydropyrazole Moiety: Synthesis and Antibacterial Activity, Letters in Drug Design & Discovery 2011; 8 (6) . https://dx.doi.org/10.2174/157018011795906857