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Current Immunology Reviews (Discontinued)


ISSN (Print): 1573-3955
ISSN (Online): 1875-631X

Herpes Simplex Virus-Induced Ocular Diseases: Detrimental Interaction Between Virus and Host

Author(s): Georges M.G.M. Verjans and Arnd Heiligenhaus

Volume 7, Issue 3, 2011

Page: [310 - 327] Pages: 18

DOI: 10.2174/157339511796196557

Price: $65


Herpes simplex virus type 1 (HSV-1) is a common cause of ocular diseases, affecting all parts of the visual axis. HSV-1 keratitis and uveitis represent two prevalent ocular diseases. The outcome of these potentially sightthreatening conditions depends on prompt diagnosis and treatment in order to counteract the detrimental intra-ocular virus-host interaction. This review recapitulates current insights on the diagnosis, pathogenesis, and treatment of HSV-1 keratitis and uveitis in patients and in the respective mouse models.

Keywords: Herpes simplex virus, keratitis, uveitis, epidemiology, clinical symptoms, diagnosis, pathogenesis, treatment, Ocular Diseases, Neurotrophic keratitis, dendritic HSV lesion, Corneal endotheliitis, Stromal keratitis, Acute retinal necrosis

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