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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Exploring the Structure Activity Relationships of Imidazole Containing Tetrahydrobenzodiazepines as Farnesyltransferase Inhibitors: A QSAR Study

Author(s): Anand Gaurav, Vertika Gautam and Ranjit Singh

Volume 8, Issue 6, 2011

Page: [506 - 515] Pages: 10

DOI: 10.2174/157018011795906758

Price: $65


Quantitative structure activity relationship approach using enhanced replacement method for variable selection was applied to a series of imidazole containing tetrahydrobenzodiazepines as inhibitors of farnesyltransferase. For the purpose the dataset was divided into training set of 31 compounds and test set of 5 compounds using k means clustering. Statistically significant equations were obtained with high correlation coefficient coefficient (R=0.9637) and low standard deviation (S=0.3715). The robustness of the model was confirmed with the help of R2cv with a value of 0.8886, Y scrambling and by predicting the activities of test compounds. A good correlation of KierA3 shape indices and polarizability with the farnesyltransferase inhibitory activity was achieved.

Keywords: QSAR, Farnesyltransferase Inhibitors, Tetrahydrobenzodiazepines, Y scrambling, Polarizability, Imidazole, Ras proteins, PFT inhibitors, metalloenzyme, GABAA, Kubinyi function (FIT), apol, Specific Polarizability, Spol(R4)

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