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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Study of Prolactin Permeation Through the Pericardium and Its Bioavailability

Author(s): Barbara Dolinska, Artur Caban, Lucyna Leszczynska, Grzegorz Oczkowicz and Florian Ryszka

Volume 18, Issue 6, 2011

Page: [540 - 544] Pages: 5

DOI: 10.2174/092986611795222704

Price: $65


The prolactin (PRL) permeation through the pericardium depending on the species of origin (porcine, bovine and ovine) was studied, and the parameters of its bioavailability were calculated. An in vitro model using pericardium as a natural membrane and Frantz cell method was applied.

Significant differences in permeation were observed depending on the species of origin. Within 5 h, 17.5% of bovine PRL, 27.2% of porcine PRL and 90.3% of ovine PRL permeated the pericardium. The amount of permeated ovine PRL was 3.3-fold higher than porcine PRL and 5.2-fold higher than bovine PRL. The maximum concentration of permeated PRL was reached in the thirtieth minute of the experiment and was the highest for ovine PRL (Cmax = 677.21 μg/cm2) and the lowest for bovine PRL (Cmax=259.97 μg/cm2). Bioavailability of PRL through the pericardium is 3.3-fold greater for ovine PRL in comparison to porcine or bovine PRL. The relative extent of bioavailability for bovine and ovine prolactin versus the porcine PRL standard was 85.6% and 229.3%, respectively.

Keywords: bioavailability, pericardium, permeation, PRL, prolactinbioavailability, pericardium, permeation, PRL, prolactin

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