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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

A Versatile and Efficient Cu-Catalyzed N-Arylation of Aromatic Cyclic Secondary Amines with Aryl Halides

Author(s): Haitao Yang, Zhiwei Miao and Ruyu Chen

Volume 8, Issue 5, 2011

Page: [325 - 331] Pages: 7

DOI: 10.2174/157017811795684974

Price: $65


A copper-catalyzed coupling reaction of aryl halides with various aromatic cyclic secondary amines in DMSO has been developed efficiently. The versatile and efficient copper catalyst system is of wide-spread and practical application in cross-coupling reactions.

Keywords: N-Arylation, Aromatic cyclic secondary amines, Copper catalyst, Cross-coupling, pharmaceutical, heterocycle, dioxane, toluene, dichloroethane, aryl halide

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