A Versatile and Efficient Cu-Catalyzed N-Arylation of Aromatic Cyclic Secondary Amines with Aryl Halides

Haitao      Yang; Zhiwei      Miao; Ruyu      Chen

Abstract

A copper-catalyzed coupling reaction of aryl halides with various aromatic cyclic secondary amines in DMSO has been developed efficiently. The versatile and efficient copper catalyst system is of wide-spread and practical application in cross-coupling reactions.

Keywords: N-Arylation, Aromatic cyclic secondary amines, Copper catalyst, Cross-coupling, pharmaceutical, heterocycle, dioxane, toluene, dichloroethane, aryl halide