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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

In Silico Studies of (2E,5E)-2,5-bis(3-methoxy-4-hydroxy-benzylidene) Cyclopentanone on Proteins AChE and BChE Involved in Alzheimers disease and Ameliorative Effects on Paraquat Induced Oxidative Stress Markers in Drosophila melanogaster

Author(s): Balladka Kunhanna Sarojini, Chenna Govindaraju Darshan Raj, Modalkoppalu Kyathegowda Ramakrishna, Saraf R Ramesh, Basavapattana Rudresh Bharath and Hanumanthappa Manjunatha

Volume 8, Issue 3, 2011

Page: [260 - 267] Pages: 8

DOI: 10.2174/157018011794578213

Price: $65


In the present study, the ameliorative effect of a bischalcone (2E,5E)-2,5-bis(3-methoxy-4-hydroxy- benzylidene) cyclopentanone (CA), a curcumin analog was studied on Drosophila melanogaster (oregon K strain) in vivo by inducing oxidative stress using paraquat. Curcumin (CU) was taken as standard for studies. In negative geotaxis assay it was found that CA was able to rescue the flies significantly from deteriorating locomotor dysfunctions. A docking study for antialzeimers activity of CA was carried out by targeting the proteins Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE). It binds effectively to the target proteins.

Keywords: Antioxidant, Alzheimer disease, Bischalcone, Paraquat, Molecular docking, Oxidative stress

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