Abstract
Septic shock is characterized by vasodilation and hypotension despite increased vasoconstrictors. While nitric oxide is known to be responsible for vasodilation, failure of vascular smooth muscle to constrict may be due in part to low plasma levels of vasopressin, a neurohypophyseal hormone. In the initial phase of septic shock, vasopressin concentration usually increases but then decreases to a significantly lower concentration after onset of septic shock. In this review, we discuss the neural mechanisms for the regulation of vasopressin secretion during septic shock.
Keywords: Endotoxic shock, hypotension, osmolality, septic shock, vasopressin
Endocrine, Metabolic & Immune Disorders - Drug Targets
Title: Neurohypophyseal Dysfunction During Septic Shock
Volume: 10 Issue: 3
Author(s): Alexandre Giusti-Paiva and Michael Brian Santiago
Affiliation:
Keywords: Endotoxic shock, hypotension, osmolality, septic shock, vasopressin
Abstract: Septic shock is characterized by vasodilation and hypotension despite increased vasoconstrictors. While nitric oxide is known to be responsible for vasodilation, failure of vascular smooth muscle to constrict may be due in part to low plasma levels of vasopressin, a neurohypophyseal hormone. In the initial phase of septic shock, vasopressin concentration usually increases but then decreases to a significantly lower concentration after onset of septic shock. In this review, we discuss the neural mechanisms for the regulation of vasopressin secretion during septic shock.
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Cite this article as:
Giusti-Paiva Alexandre and Brian Santiago Michael, Neurohypophyseal Dysfunction During Septic Shock, Endocrine, Metabolic & Immune Disorders - Drug Targets 2010; 10 (3) . https://dx.doi.org/10.2174/187153010791936838
DOI https://dx.doi.org/10.2174/187153010791936838 |
Print ISSN 1871-5303 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3873 |
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