Antimycobacterial Profile of 5-phenyl-1,3,4-thiadiazole-2-arylhydrazone Derivatives

Title: Antimycobacterial Profile of 5-phenyl-1,3,4-thiadiazole-2-arylhydrazone Derivatives

Volume: 7 Issue: 8

Author(s): Samir A. Carvalho, Edson F. da Silva, Maria C.S. Lourenco, Marcus V.N. de Souza and Carlos A.M. Fraga

Affiliation:

Keywords: 1,3,4-thiadiazoles, Antimycobacterial activity, N-arylhydrazones, Tuberculosis

Abstract: In this work we report the tuberculostatic profile of a series of 5-phenyl-1,3,4-thiadiazole-2-arylhydrazone derivatives (1a-m). The evaluation of their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv was expressed as the minimum inhibitory concentration (MIC) in μg/mL. The compounds 1g and 1h exhibited inhibitory activity of 6.25 μg/mL and 1.25 μg/mL respectively, and can be considered as a good start point for the discovery of new lead compounds in the field of multi-drug resistant tuberculosis.

Cite this article as:

A. Carvalho Samir, F. da Silva Edson, C.S. Lourenco Maria, V.N. de Souza Marcus and A.M. Fraga Carlos, Antimycobacterial Profile of 5-phenyl-1,3,4-thiadiazole-2-arylhydrazone Derivatives, Letters in Drug Design & Discovery 2010; 7 (8) . https://dx.doi.org/10.2174/157018010792062768