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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Synthesis and Antitumor Evaluation of (E)-2-Benzothiazole Hydrazones

Author(s): Antonio Francisco Nogueira, Elisa Carvalho Azevedo, Vitor Francisco Ferreira, Ana Jersia Araujo, Evelyne Alves dos Santos, Claudia Pessoa, Leticia Veras Costa-Lotufo, Raquel Carvalho Montenegro, Manoel Odorico de Moraes and Thatyana Rocha Alves Vasconcelos

Volume 7, Issue 8, 2010

Page: [551 - 555] Pages: 5

DOI: 10.2174/157018010792062740

Price: $65


A series of eleven (E)-2-benzothiazole hydrazones were synthesized and evaluated for their in vitro anticancer activities against three neoplastic cancer cells: HL-60 (leukemia), MDAMB-435 (breast) and HCT-8 (colon). Two of them, 3e and 3f, showed good cytotoxicity activity for HL-60. The results also demonstrated that compound 3f seems to be selective to HL-60 cell line, appearing as a good prototype for an antileukemia lead molecule.

Keywords: Benzothiazoles, Hydrazones, Cancer, Cytotoxicity

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