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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

One-Pot Synthesis of Enaminones Using Golds Reagent

Author(s): Tamer S. Saleh, Mohamed A. Al-Omar and Hatem A. Abdel-Aziz

Volume 7, Issue 6, 2010

Page: [483 - 486] Pages: 4

DOI: 10.2174/157017810791824793

Price: $65


Enaminones were efficiently prepared via modification for Gupton method, which depends on carrying out the latter procedure in one step reaction, avoiding the isolation of [3-(dimethylamino)-2-azaprop-2-en-1- ylidene]dimethylammonium chloride (Golds reagent) (5) which is prepared in situ from cyanuric chloride (4) then it reacts successfully with ketone 1a-j to produce the enaminones 3a-j in suitable yields. The modified method overcomes the drawbacks of the known methods for preparation of enaminones.

Keywords: Enaminone, cyanuric chloride, gold's reagent, DMF-DMA, Ketone

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