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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Synthesis of Pyrrolizidine Derivatives in Ionic Liquid [bmim] Br

Author(s): Laleh Faraji, Hamid Arvinnezhad, Naghmeh Alikami and Khosrow Jadidi

Volume 7, Issue 6, 2010

Page: [472 - 474] Pages: 3

DOI: 10.2174/157017810791824946

Price: $65


Pyrrolizidines were synthesized from 1,3-dipolar cycloaddition of N-substituted isatins, proline, and olefins. The highly diastereoselective and regioselective one-pot three-component cyclocondensation products were obtained in the presence of ionic liquids such as 1-buthyl-3-methlylimidazolium bromide.

Keywords: Pyrrolizidines, ionic liquid, isatine, diastereoselective, 1,3-dipolar cycloaddition

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