Abstract
A screening of different metal triflates as catalysts was performed to get isochromans through an oxa-Pictet- Spengler reaction. Good to high yields were obtained for various aliphatic or aromatic aldehydes and β-arylethanols. A mechanism involving catalysis by in situ liberated triflic acid to catalyse the isochroman ring formation is proposed.
Keywords: Metal triflate, oxa-Pictet-Spengler, catalysis
Letters in Organic Chemistry
Title: Metal Triflates: Efficient Catalysts for Oxa-Pictet-Spengler Reaction
Volume: 7 Issue: 6
Author(s): Benaissa Bouguerne, Christian Lherbet and Michel Baltas
Affiliation:
Keywords: Metal triflate, oxa-Pictet-Spengler, catalysis
Abstract: A screening of different metal triflates as catalysts was performed to get isochromans through an oxa-Pictet- Spengler reaction. Good to high yields were obtained for various aliphatic or aromatic aldehydes and β-arylethanols. A mechanism involving catalysis by in situ liberated triflic acid to catalyse the isochroman ring formation is proposed.
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Cite this article as:
Bouguerne Benaissa, Lherbet Christian and Baltas Michel, Metal Triflates: Efficient Catalysts for Oxa-Pictet-Spengler Reaction, Letters in Organic Chemistry 2010; 7 (6) . https://dx.doi.org/10.2174/157017810791824883
DOI https://dx.doi.org/10.2174/157017810791824883 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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