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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Synthesis and Cytotoxic Activities of 2-(4-(2-heterocycloethoxy)phenyl)- 1,2,4-triazolo[1,5-a] Pyridines

Author(s): Guolin Zhang and Jun Chen

Volume 8, Issue 3, 2011

Page: [180 - 183] Pages: 4

DOI: 10.2174/157017811795038377

Price: $65


Nine 2-(4-(2-heterocycloethoxy)phenyl)-1,2,4-triazolo[1,5-a] pyridines have been synthesized. The structures of all products were confirmed by 1H NMR and HRMS. The cytotoxic activities of these compounds were evaluated against human ovary cancer cell line (HO-8910) in vitro by MTT method. The preliminary results showed that compound 4e (IC50 0.11mM) and compound 4f (IC50 0.11mM) exhibited moderate activity against the cancer cell line when compared with Cisplatin.

Keywords: Synthesis, cytotoxic, 1,2,4-triazolo[1,5-a] pyridines, benzyloxyphenyl, methyl, fungi, cycloethoxy, phenyl, ethyloxyphenyl, morpholino

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