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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Crystal Structure of the Apo Form of D-Alanine:D-Alanine Ligase (DDl) from Streptococcus mutans

Author(s): Yongzhi Lu, Hongyan Xu and Xiaojun Zhao

Volume 17, Issue 8, 2010

Page: [1053 - 1057] Pages: 5

DOI: 10.2174/092986610791498858

Price: $65

Abstract

D-Alanine:D-Alanine ligase (DDl) catalyzes the formation of D-Alanine:D-Alanine dipeptide and is an essential enzyme in bacterial cell wall biosynthesis. This enzyme does not have a human ortholog, making it an attractive target for developing new antibiotic drugs. We determined the crystal structure at 2.23 Å resolution of DDl from Streptococcus mutans (SmDDl), the principal aetiological agent of human dental caries. This structure reveals that SmDDl is a dimer and has a disordered ω-loop region.

Keywords: X-ray crystal structure, amino acids and peptides, DDl, Streptococcus mutans


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