Synthesis of Natural Products Using Intramolecular Dipolar Cycloaddition Reactions

Title: Synthesis of Natural Products Using Intramolecular Dipolar Cycloaddition Reactions

Volume: 7 Issue: 4

Author(s): Adam J.M. Burrell and Iain Coldham

Affiliation:

Keywords: Cycloaddition, dipoles, natural products, synthesis, ylides

Abstract: This review describes ylide 1,3-dipoles in cycloaddition reactions for the synthesis (and formal synthesis) of natural products. Examples using azomethine ylides, carbonyl ylides, nitrones, nitronates, nitrile oxides and azides are provided. These lead to a diverse array of heterocyclic products. Intramolecular cycloaddition provides two new rings in one step and hence an efficient entry to complex target compounds.

Cite this article as:

J.M. Burrell Adam and Coldham Iain, Synthesis of Natural Products Using Intramolecular Dipolar Cycloaddition Reactions, Current Organic Synthesis 2010; 7(4) . https://dx.doi.org/10.2174/157017910791414472