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Current Organic Synthesis


ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Synthesis of Natural Products Using Intramolecular Dipolar Cycloaddition Reactions

Author(s): Adam J.M. Burrell and Iain Coldham

Volume 7, Issue 4, 2010

Page: [312 - 331] Pages: 20

DOI: 10.2174/157017910791414472

Price: $65


This review describes ylide 1,3-dipoles in cycloaddition reactions for the synthesis (and formal synthesis) of natural products. Examples using azomethine ylides, carbonyl ylides, nitrones, nitronates, nitrile oxides and azides are provided. These lead to a diverse array of heterocyclic products. Intramolecular cycloaddition provides two new rings in one step and hence an efficient entry to complex target compounds.

Keywords: Cycloaddition, dipoles, natural products, synthesis, ylides

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