Synthesis and Antitumor Activity of 2-Aryl-1, 2, 4-Triazolo[1, 5-a] Pyridine Derivatives

Title: Synthesis and Antitumor Activity of 2-Aryl-1, 2, 4-Triazolo[1, 5-a] Pyridine Derivatives

Volume: 6 Issue: 2

Author(s): Xuefen Tao and Yongzhou Hu

Affiliation:

Keywords: Synthesis, antitumor activity, 2- aryl-1, 2, 4, –, triazolo [1, 5-a] pyridine

Abstract: A novel series of 2-aryl-1, 2, 4 – triazolo [1, 5-a] pyridine derivatives have been synthesized and evaluated for their cytotoxic activities in vitro against Human ovarian cancer cell line (HO-8910) and Human liver cancer cell line (Bel 7402). Most compounds showed high or mediate activity against the cancer cell lines when compared with Cisplatin. Two of them were tested the apoptosis on Bel 7402.

Cite this article as:

Tao Xuefen and Hu Yongzhou, Synthesis and Antitumor Activity of 2-Aryl-1, 2, 4-Triazolo[1, 5-a] Pyridine Derivatives, Medicinal Chemistry 2010; 6(2) . https://dx.doi.org/10.2174/157340610791321505