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Medicinal Chemistry


ISSN (Print): 1573-4064
ISSN (Online): 1875-6638

Synthesis and Antitumor Activity of 2-Aryl-1, 2, 4-Triazolo[1, 5-a] Pyridine Derivatives

Author(s): Xuefen Tao and Yongzhou Hu

Volume 6, Issue 2, 2010

Page: [65 - 69] Pages: 5

DOI: 10.2174/157340610791321505

Price: $65


A novel series of 2-aryl-1, 2, 4 – triazolo [1, 5-a] pyridine derivatives have been synthesized and evaluated for their cytotoxic activities in vitro against Human ovarian cancer cell line (HO-8910) and Human liver cancer cell line (Bel 7402). Most compounds showed high or mediate activity against the cancer cell lines when compared with Cisplatin. Two of them were tested the apoptosis on Bel 7402.

Keywords: Synthesis, antitumor activity, 2- aryl-1, 2, 4, , triazolo [1, 5-a] pyridine

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