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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Synthesis and In-Vitro Antitumor Activity of Selected 7-Fluoro-6-(4-methyl-1-piperazinyl)-2-(thiosubstituted)-4(3H)-quinazolinones

Author(s): Raid J. Abdel-Jalil, Ehab Al-Momani, Lubna Tahtamooni, H.-Juergen Machulla and Wolfgang Voelter

Volume 7, Issue 5, 2010

Page: [360 - 366] Pages: 7

DOI: 10.2174/157017810791514751

Price: $65


A new series of 7-fluoro-6-(4-methyl-1-piperazinyl)-2-(thiosubstituted)-4(3H)-quinazolinones was synthesized as potential antitumor agents by multi-step synthesis starting with the commercially available 3-chloro-4-fluoroaniline. The most promising candidate, 7-fluoro-6-(4- methyl-1-thyl-1-piperazinyl)- 2-thioethyl-4(3H)-quinazolinone (5a), was screened in 60 human cancer cells by NCI.

Keywords: Quinazolinone derivatives, piperazine derivatives, anticancer activity

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