Abstract
While at present there is no scientific consensus on the reasons for cellular and organismal ageing - or indeed on a comprehensive definition for ageing - scientific efforts to unravel the complex biochemistry behind the ageing process have recently met with considerable success. Despite a still somewhat fragmented understanding of the phenomenon of ageing, a distinction has therefore become possible between those biochemical and physiological events that are causal to ageing, and those that merely accompany the process. Such a distinction is an important prerequisite for the selection of targets for pharmacological intervention, and for the design of “antiageing drugs” directed against these targets. This review looks from a chemical viewpoint at currently used model systems for the ageing process, at small molecules showing anti-ageing properties in these screens, and at their mechanisms of action.
Keywords: Saccharomyces cerevisiae, Superoxide Dismutase, Drosophila melanogaster, Trichostatin A, Anticonvulsants
Current Drug Targets
Title: Towards a Life Prolonging Pill? Small Molecules with Anti-Ageing Properties
Volume: 7 Issue: 11
Author(s): Manuchair Wagner
Affiliation:
Keywords: Saccharomyces cerevisiae, Superoxide Dismutase, Drosophila melanogaster, Trichostatin A, Anticonvulsants
Abstract: While at present there is no scientific consensus on the reasons for cellular and organismal ageing - or indeed on a comprehensive definition for ageing - scientific efforts to unravel the complex biochemistry behind the ageing process have recently met with considerable success. Despite a still somewhat fragmented understanding of the phenomenon of ageing, a distinction has therefore become possible between those biochemical and physiological events that are causal to ageing, and those that merely accompany the process. Such a distinction is an important prerequisite for the selection of targets for pharmacological intervention, and for the design of “antiageing drugs” directed against these targets. This review looks from a chemical viewpoint at currently used model systems for the ageing process, at small molecules showing anti-ageing properties in these screens, and at their mechanisms of action.
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Cite this article as:
Wagner Manuchair, Towards a Life Prolonging Pill? Small Molecules with Anti-Ageing Properties, Current Drug Targets 2006; 7 (11) . https://dx.doi.org/10.2174/1389450110607011531
DOI https://dx.doi.org/10.2174/1389450110607011531 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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