Evaluation of Novel 7-(hetero)aryl-substituted Pyrazolo[1, 5-a]pyrimidines as Phosphodiesterase-4 Inhibitors

Title: Evaluation of Novel 7-(hetero)aryl-substituted Pyrazolo[1, 5-a]pyrimidines as Phosphodiesterase-4 Inhibitors

Volume: 7 Issue: 6

Author(s): Arumugam Kodimuthali, Rajesh Gupta, Kishore Venkata Laxmi Parsa, Padala Lakshmi Prasunamba and Manojit Pal

Affiliation:

Keywords: PDE4, Rolipram, Inhibitor, Pyrazolopyrimidine

Abstract: A novel series of 7-(hetero)aryl substituted-pyrazolopyrimidines, prepared via an AlCl3 induced C-C bond forming reaction of 7-chloro-5-phenyl-pyrazolo[1,5-a]pyrimidine with arenes and heteroarenes have been investigated as PDE4 inhibitors. Among all the compounds tested the 7-indolyl substituted pyrazolopyrimidine showed good inhibition of PDE 4 in vitro.

Cite this article as:

Kodimuthali Arumugam, Gupta Rajesh, Venkata Laxmi Parsa Kishore, Lakshmi Prasunamba Padala and Pal Manojit, Evaluation of Novel 7-(hetero)aryl-substituted Pyrazolo[1, 5-a]pyrimidines as Phosphodiesterase-4 Inhibitors, Letters in Drug Design & Discovery 2010; 7 (6) . https://dx.doi.org/10.2174/157018010791306542