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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Antioxidant Enzyme Mimics with Synergism

Author(s): Fei Yan, Ying Mu, Ganglin Yan, Junqiu Liu, Jiacong Shen and Guimin Luo

Volume 10, Issue 4, 2010

Page: [342 - 356] Pages: 15

DOI: 10.2174/138955710791330972

Price: $65


The antioxidant enzymes, such as superoxide dismutase, catalase, glutathione peroxidase, and glutathione S-transferase contribute dominatingly to enhance cellular antioxidant defense against oxidative stress. They act cooperatively to scavenge reactive oxygen species, and not one of them can singlehandedly clear all forms of reactive oxygen species. On the basis of the structural understanding for these natural enzymes, many mimics with multifunctional activities had been obtained by chemical synthesis, biosynthesis, and protein fusion techniques. Some of them display remarkable antioxidant cooperative effect in living model which possess potential application in medicine as potent antioxidants. This review summarizes aspects of some multifunctional mimics which have been reported so far.

Keywords: Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione S-transferases (GST), reactive oxygen species (ROS), antioxidant enzymes, enzyme mimics, synergism

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