Abstract
AIDS, the fatal disease, caused in human by the fast spreading human immunodeficiency virus (HIV), was detected in 1981. To check its rapid growth, affecting various parts of the world population, there are various FDA approved drugs, released in the market for treating AIDS. These belong to 5 different categories which differ in their mechanism of action. These are i) reverse transcriptase inhibitors, ii) protease inhibitors, iii) fusion inhibitors, iv) entry inhibitors and v) HIV integrase strand transfer inhibitors. These drugs are mostly used in a combination therapy, named as Highly Active Anti Retroviral Therapy (HAART), using 2 to 3 compounds in combination, for a more effective and beneficial treatment. However, none of the drugs can be considered ideal for curing the disease. A study of structural requirement for different types of anti-HIV activities may help in designing a suitable drug for AIDS.
Keywords: Anti HIV, AIDS, protease inhibitor, reverse transcriptase inhibitor, integrase inhibitor, fusion inhibitor
Mini-Reviews in Medicinal Chemistry
Title: Drugs for AIDS
Volume: 10 Issue: 2
Author(s): S. Ray, Z. Fatima and A. Saxena
Affiliation:
Keywords: Anti HIV, AIDS, protease inhibitor, reverse transcriptase inhibitor, integrase inhibitor, fusion inhibitor
Abstract: AIDS, the fatal disease, caused in human by the fast spreading human immunodeficiency virus (HIV), was detected in 1981. To check its rapid growth, affecting various parts of the world population, there are various FDA approved drugs, released in the market for treating AIDS. These belong to 5 different categories which differ in their mechanism of action. These are i) reverse transcriptase inhibitors, ii) protease inhibitors, iii) fusion inhibitors, iv) entry inhibitors and v) HIV integrase strand transfer inhibitors. These drugs are mostly used in a combination therapy, named as Highly Active Anti Retroviral Therapy (HAART), using 2 to 3 compounds in combination, for a more effective and beneficial treatment. However, none of the drugs can be considered ideal for curing the disease. A study of structural requirement for different types of anti-HIV activities may help in designing a suitable drug for AIDS.
Export Options
About this article
Cite this article as:
Ray S., Fatima Z. and Saxena A., Drugs for AIDS, Mini-Reviews in Medicinal Chemistry 2010; 10 (2) . https://dx.doi.org/10.2174/138955710791185145
DOI https://dx.doi.org/10.2174/138955710791185145 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
Natural Products in Drug Discovery
Natural products have always been one of the important ways of drug discovery due to their novel skeleton and diverse functional group characteristics. According to statistics, between 1981 and 2019, the FDA approved a total of 1,394 small molecule drugs for marketing, of which 930 marketed drugs originated from the ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Treatment of Diabetic Foot Ulcers
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Monoamine Receptors in the Regulation of Feeding Behaviour and Energy Balance
CNS & Neurological Disorders - Drug Targets Improved Sensory Blockade by Clonidine Added to Axillary Block Solution. Resulting Plasma Clonidine Concentration
Letters in Drug Design & Discovery The Role of Pro-Inflammatory Molecules and Pharmacological Agents in Acute Pancreatitis and Sepsis
Inflammation & Allergy - Drug Targets (Discontinued) Vasopressin and Oxytocin in Control of the Cardiovascular System
Current Neuropharmacology Current Pharmaceutical Treatments and Alternative Therapies of Parkinson’s Disease
Current Neuropharmacology The Interactions of Anticancer Agents with Tea Catechins: Current Evidence from Preclinical Studies
Anti-Cancer Agents in Medicinal Chemistry Hypertension in Chronic Kidney Disease: Novel Insights
Current Hypertension Reviews Monoclonal Antobodies: Application in Radiopharmacy
Current Radiopharmaceuticals Biosynthetic Pathways of Bioactive N-Acylethanolamines in Brain
CNS & Neurological Disorders - Drug Targets Therapeutic Targeting of TRPV1 by Resiniferatoxin, from Preclinical Studies to Clinical Trials
Current Topics in Medicinal Chemistry High Blood Pressure and the Risk of Stroke
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Inhibitory Effect of PD-1/PD-L1 and Blockade Immunotherapy in Leukemia
Combinatorial Chemistry & High Throughput Screening Targeting TNF-Alpha to Elucidate and Ameliorate Neuroinflammation in Neurodegenerative Diseases
CNS & Neurological Disorders - Drug Targets Cardiac and Metabolic Consequences of Aerobic Exercise Training in Experimental Diabetes
Current Diabetes Reviews Oxidative Stress and Mitochondrial Dysfunction in Sepsis: A Potential Therapy with Mitochondria-Targeted Antioxidants
Infectious Disorders - Drug Targets Critical Questions for Preclinical Trials on Safety and Efficacy of Vascular Endothelial Growth Factor-Based Therapeutic Angiogenesis for Ischemic Stroke
CNS & Neurological Disorders - Drug Targets Editorial
Current Pediatric Reviews Insulin Neuritis and Diabetic Cachectic Neuropathy: A Review
Current Diabetes Reviews Investigational Positive Inotropic Agents for Acute Heart Failure
Cardiovascular & Hematological Disorders-Drug Targets