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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

The First Kinetic Enzymatic Resolution of Methyl Ester of C75

Author(s): Kuheli Chakrabarty, Cristina Forzato, Patrizia Nitti, Giuliana Pitacco and Ennio Valentin

Volume 7 , Issue 3 , 2010

Page: [245 - 248] Pages: 4

DOI: 10.2174/157017810791112405

Price: $65


Enantioselective hydrolysis of methyl ester of (±)-C75 was successfully accomplished by means of Acylase I from Aspergillus to afford (2R,3S)-(+)-C75 with 96% e.e. The unreacted methyl ester was recovered with > 99% e.e. This latter compound was either chemically or enzymatically hydrolyzed to furnish (2S,3R)-( – )-C75 with > 99% e.e.

Keywords: C75, enzymatic resolution, α-methylene-γ-butyrolactone, paraconic acid, Acylase I

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