Abstract
Chiral phosphoric acid as organocatalyst for the diastereo- and enantioselectivity 1,4-conjugate addition of a variety of β-ketoesters to nitroolefins was firstly developed, providing the corresponding adducts in high yield (up to 97%) with moderate diastereoselectivities (up to 2.6:1 dr) and enantioselectivities (up to 58% ee).
Keywords: Chiral phosphoric acid, organocatalysis, asymmetric catalysis, 1,4-conjugate addition, β-ketoesters, nitroolefins
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Carbohydrates: Synthesis, properties and applications
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