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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Non-Invasive Approaches to Visualize the Endothelin Axis In Vivo Using State-of-the-Art Molecular Imaging Modalities

Author(s): C. Holtke, A. Faust, H-J. Breyholz, K. Kopka, O. Schober, B. Riemann, C. Bremer, M. Schafers and S. Wagner

Volume 9, Issue 14, 2009

Page: [1580 - 1595] Pages: 16

DOI: 10.2174/138955709791012210

Price: $65


The endothelin (ET) axis plays a major role in cardiovascular diseases and a number of human cancers. This review summarizes the work that has been published in the past ten years using labeled endothelin receptor ligands for the visualization of endothelin receptor expression in vivo.

Keywords: Molecular imaging, endothelin axis, tumor angiogenesis, endothelial dysfunction, cardiovascular diseases

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