Generic placeholder image

Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Drastic Effects on Fibril Formation of Amyloid-β Peptides by the Addition of Amino Acid Residue Units to the Termini

Author(s): Yuya Asanomi, Yumiko Kobayashi, Hiroki Sakai, Takuya Masuda, Xinjiang Chen, Yoshiro Chuman, Kohei Uosaki and Kazuyasu Sakaguchi

Volume 17, Issue 4, 2010

Page: [458 - 463] Pages: 6

DOI: 10.2174/092986610790963618

Price: $65


We report that the addition of amino acids to the amyloid peptide dramatically affected the structure and the rate of formation of amyloid fibrils. The attachment of three lysines to Aβ(10-35) gave the formation of remarkably long fibrils, while three glutamates resulted in a faster formation rate of the fibrils.

Keywords: , amyloid, atomic force microscopy, bionanomaterial, fibril formation, self-assembly

Rights & Permissions Print Export Cite as
© 2023 Bentham Science Publishers | Privacy Policy