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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Enzymatic Synthesis of Dipeptides in Ionic Liquids

Author(s): Sanjay V. Malhotra, Chengdong Zhang and Hao Wang

Volume 7, Issue 2, 2010

Page: [168 - 171] Pages: 4

DOI: 10.2174/157017810790796318

Price: $65


Immobilized protease-catalyzed synthesis of peptides from natural amino acids has been achieved in ionic liquids (ILs). Three ionic liquids BMIM.PF6, BMIM.BF4 and EtPy.BF4 have been tested; an effective yet simple and practical method has been devised. The product yields are comparable with those seen in molecular solvents. A max yield of 49 % for Boc-Leu-TrpOEt has been obtained. This study shows that the advantages seen in organic solvents can also be achieved in ILs, and use of such medium could provide a viable alternative to organic and aqueous media for biocatalysis.

Keywords: Enzymatic synthesis, protease, dipeptides, ionic liquid

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