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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Benzoxazine and Benzodioxine as Indole Isosteres in Indolocarbazoles Series: Synthesis and Biological Evaluation

Author(s): Nathalie Ayerbe, Sylvain Routier, Isabelle Gillaizeau, Sebastien Tardy and Gerard Coudert

Volume 7, Issue 2, 2010

Page: [121 - 126] Pages: 6

DOI: 10.2174/157017810790796291

Price: $65


New series of structure based on original benzodioxine and benzoxazine heterocycles were prepared leading to potential anticancer lead compounds. In this paper, we described a convenient approach via a Diels-Alder cycloaddition in order to efficiently provide three new indole isosteres in indolocarbazoles series. Their first cytotoxic evaluation was also reported.

Keywords: Benzodioxine, benzoxazine, indolocarbazole, cytotoxicity

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