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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

A Convenient Methodology for Nitro-Michael Addition of Carbonyl Compounds Catalyzed by L-Proline Using Microwave Heating

Author(s): Alessio Russo, Nicholas E. Leadbeater and Alessandra Lattanzi

Volume 7, Issue 2, 2010

Page: [98 - 102] Pages: 5

DOI: 10.2174/157017810790796219

Price: $65


Michael addition of aldehydes and ketones to trans-β-nitrostyrene catalyzed by L-proline was investigated using microwave heating for rapid optimization of reaction conditions. The products could be obtained, easily in very short reaction times, high yields and comparable diastereo- and enantioselectivity with respect to the original procedures, under simple and more environmentally benign conditions such as the use of ethanol as the solvent and only a slight excess of the carbonyl compound.

Keywords: Michael addition, organocatalysis, L-proline, carbonyl compounds, microwave irradiation, conventional heating

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