Interactions of Ginkgolides A and B with a Recombinant Human Prion Protein

Title: Interactions of Ginkgolides A and B with a Recombinant Human Prion Protein

Volume: 17 Issue: 3

Author(s): Dessislava Georgieva, Lars Redecke, Martin von Bergen, Nicolay Genov and Chrsitian Betzel

Affiliation:

Keywords: Three-dimensional structure, structural transformation, ginkgolide, prion protein, protein misfolding

Abstract: In the presence of ginkgolides A and B a recombinant human prion protein (90-231) is more susceptible to proteolysis, which is characteristic for the non-infective form of prion proteins and more thermostable than in the absence of ginkgolides. Probably, ginkgolides exert a neuroprotective effect through a rearrangement of the prion structure.

Cite this article as:

Georgieva Dessislava, Redecke Lars, Bergen von Martin, Genov Nicolay and Betzel Chrsitian, Interactions of Ginkgolides A and B with a Recombinant Human Prion Protein, Protein & Peptide Letters 2010; 17(3) . https://dx.doi.org/10.2174/092986610790780314