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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Interactions of Ginkgolides A and B with a Recombinant Human Prion Protein

Author(s): Dessislava Georgieva, Lars Redecke, Martin von Bergen, Nicolay Genov and Chrsitian Betzel

Volume 17, Issue 3, 2010

Page: [399 - 404] Pages: 6

DOI: 10.2174/092986610790780314

Price: $65


In the presence of ginkgolides A and B a recombinant human prion protein (90-231) is more susceptible to proteolysis, which is characteristic for the non-infective form of prion proteins and more thermostable than in the absence of ginkgolides. Probably, ginkgolides exert a neuroprotective effect through a rearrangement of the prion structure.

Keywords: Three-dimensional structure, structural transformation, ginkgolide, prion protein, protein misfolding

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