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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Direct Functionalization of Benzoquinolines

Author(s): Victor Mamane, Frederic Louerat and Yves Fort

Volume 7, Issue 1, 2010

Page: [90 - 93] Pages: 4

DOI: 10.2174/157017810790533986

Price: $65


The first direct lithiation of the pyridine ring of benzo[h]- and benzo[f]- quinolines is reported. The method allowed the introduction of different electrophiles (Cl, Br and SPh) in 2-position. Other groups were introduced by direct nucleophilic addition of alkyllithiums allowing further transformations to functional groups such as esters and thiolesters.

Keywords: Benzoquinoline, functionalization, lithiation, addition

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