Abstract
An economic, efficient access to 4H-chromene derivatives was found. In the presence of threo-(1S,2S)-2- amino-1-(4-nitrophenyl)-1,3-propanediol, a chiral “waste” in the production of chloromycetin, and one-pot threecomponent Hantzsch reaction of dimedone, aldehydes and malononitrile at room temperature furnished 4H-pyran derivatives in good to excellent yield.
Keywords: 4H-chromene, Hantzsch reaction, one-pot synthesis, threo-(1S,2S)-2-amino-1-(4-nitrophenyl)-1, 3-propanediol
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