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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

A Cheap Amino Alcohol Catalyzed One-Pot, Tri-Component Synthesis of Tetrahydrochromene Derivatives

Author(s): Shaojun Song, Zixing Shan and Yong Jin

Volume 7, Issue 1, 2010

Page: [64 - 68] Pages: 5

DOI: 10.2174/157017810790534011

Price: $65


An economic, efficient access to 4H-chromene derivatives was found. In the presence of threo-(1S,2S)-2- amino-1-(4-nitrophenyl)-1,3-propanediol, a chiral “waste” in the production of chloromycetin, and one-pot threecomponent Hantzsch reaction of dimedone, aldehydes and malononitrile at room temperature furnished 4H-pyran derivatives in good to excellent yield.

Keywords: 4H-chromene, Hantzsch reaction, one-pot synthesis, threo-(1S,2S)-2-amino-1-(4-nitrophenyl)-1, 3-propanediol

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