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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Synthesis of 2,3 and 4,5-Dihydro-hydroxy-isoxazoles and Isoxazoles Under Different pH Conditions

Author(s): Virginie Andrzejak, Regis Millet, Jamal El Bakali, Abdelhalim Guelzim, Sebastien Gluszok, Philippe Chavatte, Jean-Paul Bonte, Claude Vaccher and Emmanuelle Lipka

Volume 7, Issue 1, 2010

Page: [32 - 38] Pages: 7

DOI: 10.2174/157017810790533922

Price: $65

Abstract

Reaction between aryl 1,3-diketoesters 2a-e and hydroxylamine hydrochloride has been investigated under different experimental conditions. Whereas acid conditions gave principally 3,5-isoxazole esters (3a-e), reactions under neutral and basic conditions led to different 4,5 and 2,3-dihydro-hydroxy-isoxazoles 4a-e and 5a-e.

Keywords: Isoxazoles, dihydro-hydroxy-isoxazoles, aryl 1,3-diketoesters, hydroxylamine


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