Abstract
Hydrophobic interactions are some of the most important interactions in nature. They are the primary driving force in a number of phenomena. This is mostly an entropic effect and can account for a number of biophysical events such as protein-protein or protein-ligand binding that are of immense importance in drug design. The earliest studies on this phenomenon can be dated back to the end of the 19th century when Meyer and Overton independently correlated the hydrophobic nature of gases to their anesthetic potency. Since then, significant progress has been made in this realm of science. This review briefly traces the history of hydrophobicity research along with the theoretical estimation of partition coefficients. Finally, the application of hydrophobicity estimation methods in the field of drug design and protein folding is discussed.
Keywords: Hydrophobicity, Drug Design, LogP, HINT, QSAR, Protein Folding, Hydrophobicity Scales, Hydrophobic Interactions
Current Topics in Medicinal Chemistry
Title: Hydrophobicity - Shake Flasks, Protein Folding and Drug Discovery
Volume: 10 Issue: 1
Author(s): Aurijit Sarkar and Glen E. Kellogg
Affiliation:
Keywords: Hydrophobicity, Drug Design, LogP, HINT, QSAR, Protein Folding, Hydrophobicity Scales, Hydrophobic Interactions
Abstract: Hydrophobic interactions are some of the most important interactions in nature. They are the primary driving force in a number of phenomena. This is mostly an entropic effect and can account for a number of biophysical events such as protein-protein or protein-ligand binding that are of immense importance in drug design. The earliest studies on this phenomenon can be dated back to the end of the 19th century when Meyer and Overton independently correlated the hydrophobic nature of gases to their anesthetic potency. Since then, significant progress has been made in this realm of science. This review briefly traces the history of hydrophobicity research along with the theoretical estimation of partition coefficients. Finally, the application of hydrophobicity estimation methods in the field of drug design and protein folding is discussed.
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Cite this article as:
Sarkar Aurijit and Kellogg E. Glen, Hydrophobicity - Shake Flasks, Protein Folding and Drug Discovery, Current Topics in Medicinal Chemistry 2010; 10 (1) . https://dx.doi.org/10.2174/156802610790232233
DOI https://dx.doi.org/10.2174/156802610790232233 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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