Molecular Modeling of Human BAD, a Pro-Apoptotic Bcl-2 Family Member, Integrating Glycolysis and Apoptosis

Title: Molecular Modeling of Human BAD, a Pro-Apoptotic Bcl-2 Family Member, Integrating Glycolysis and Apoptosis

Volume: 17 Issue: 2

Author(s): Jie Yang

Affiliation:

Keywords: Computational modeling, protein-protein interaction, sequence alignment

Abstract: Comparison between the BAD complexes indicated that BAD all docks a hydrophobic surface of PKAc regardless of its phosphorylation. PKAc may prevent Bcl-xL from rebinding to BAD by phosphorylating human BAD at Ser118; whereas human BAD is phosphorylated on Ser75 in a BAD-Bcl-xL complex, resulting in the dissociation of BAD.

Cite this article as:

Yang Jie, Molecular Modeling of Human BAD, a Pro-Apoptotic Bcl-2 Family Member, Integrating Glycolysis and Apoptosis, Protein & Peptide Letters 2010; 17 (2) . https://dx.doi.org/10.2174/092986610790226003