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Mini-Reviews in Organic Chemistry


ISSN (Print): 1570-193X
ISSN (Online): 1875-6298

Isomannide and Derivatives. Chemical and Pharmaceutical Applications

Author(s): E. M.F. Muri, B. A. Abrahim, T. G. Barros, J. S. Williamson and O. A.C. Antunes

Volume 7, Issue 1, 2010

Page: [75 - 83] Pages: 9

DOI: 10.2174/1570193X11007010075

Price: $65


Isomannide, 1,4:3,6-dianhydro-D-mannitol, is a commercially available chiral carbohydrate derived from ready dehydration of naturally occurring D-mannitol. This compound and its derivatives have been widely used in many areas such as building blocks for polymers synthesis, pharmaceutically important compounds, catalysts in asymmetric synthesis, chiral auxiliaries, and recently, in the synthesis of ionic liquids. In this review we show examples of these applications of isomannide and derivatives.

Keywords: Isomannide, chiral auxiliaries, catalysts, protease

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