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Mini-Reviews in Organic Chemistry


ISSN (Print): 1570-193X
ISSN (Online): 1875-6298

Naturally Occuring Pyrrolo[1,4]benzodiazepines in Bacteria

Author(s): Serge Fotso

Volume 7, Issue 1, 2010

Page: [68 - 74] Pages: 7

DOI: 10.2174/1570193X11007010068

Price: $65


Pyrrolo[1,4]benzodiazepines (PBDs) are a growing group of microbial secondary metabolites that showed remarkable biological activities particularly against tumor cells. Their antitumor activity is mainly due to their specifically binding to DNA and other polydeoxynucleotides to form irreversibly polymer-bound drugs. Consequently, they have been the target of several syntheses as well as screening of natural sources to discover new members. This review provides an update on recent discoveries of PBDs as well as a compilation of spectroscopic data described in the literature.

Keywords: Pyrrolo[1,4]benzodiazepines (PBDs), biological activity, natural products

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