Abstract
Since the rediscovery of proline as a catalyst in aldol reaction in 2000 by List, Barbas and Lerner and, soon after, the development of imonium catalysis by D. W. C. MacMillan, the emergence of Organocatalysis as an important instrument in Organic Synthesis is outstanding. Nowadays, one of the most important goals for chemist is the quest for new and more efficient catalysts. One emerging tool for improving existent organocatalysts consists in using additives which interact with the catalysts via supramolecular interactions such as hydrogen bonding. These interactions provide better catalysts in terms of activity and selectivity. The present review aims to cover and discuss the current evolution of this fast growing field.
Keywords: Organocatalysis, hydrogen bond, supramolecular interactions, enantioselective catalysis
Call for Papers in Thematic Issues
Navigating the 2D Universe in Organic Chemistry
This special issue explores the transformative impact of two-dimensional (2D) materials on the realm of organic chemistry, unraveling new possibilities for synthesis, functionalization, and applications of organic compounds. Focused on the unique chemistry within this novel dimension, the issue highlights breakthroughs in the field of 2D organic chemistry. Contributions are ...read more
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