Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) has been recognized as an in-hospital acquired pathogen responsible for an increasing number of cases of hospital and ventilator associated pneumonia. However, this previously considered a purely nosocomial pathogen has been diagnosed with increasing frequency at hospital admission and new infections and outbreaks have been reported in individuals from the community with absence of risk factors. This new strain of MRSA is currently recognized in the literature as community-associated MRSA (CA-MRSA). The spectrum of infections due to CA-MRSA can range from simple cutaneous abscesses and soft tissue infections to septic shock and severe necrotizing pneumonia. CA-MRSA pneumonia usually presents in a previously healthy individual with the presence of a previous influenza like illness followed by shortness of breath, bilateral pulmonary infiltrates, sepsis and prompt clinical detriment and death if no proper treatment is established soon. The objective of this review is to familiarize the clinician with CA-MRSA as cause of community acquired pneumonia, review the epidemiological, clinical, microbiological characteristics, in order to minimize delays in the administration of the adequate antimicrobial treatment to improve patients outcomes of this deadly condition.
Keywords: Pneumonia, MRSA, microbiology, diagnosis, antimicrobials
Current Respiratory Medicine Reviews
Title: Community-Associated Methicillin Resistant Staphylococcus aureus Pneumonia (CA-MRSA)
Volume: 6 Issue: 3
Author(s): Marcela Mazo, John E. Stupka, Eric M. Mortensen, Antonio Anzueto and Marcos I. Restrepo
Affiliation:
Keywords: Pneumonia, MRSA, microbiology, diagnosis, antimicrobials
Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) has been recognized as an in-hospital acquired pathogen responsible for an increasing number of cases of hospital and ventilator associated pneumonia. However, this previously considered a purely nosocomial pathogen has been diagnosed with increasing frequency at hospital admission and new infections and outbreaks have been reported in individuals from the community with absence of risk factors. This new strain of MRSA is currently recognized in the literature as community-associated MRSA (CA-MRSA). The spectrum of infections due to CA-MRSA can range from simple cutaneous abscesses and soft tissue infections to septic shock and severe necrotizing pneumonia. CA-MRSA pneumonia usually presents in a previously healthy individual with the presence of a previous influenza like illness followed by shortness of breath, bilateral pulmonary infiltrates, sepsis and prompt clinical detriment and death if no proper treatment is established soon. The objective of this review is to familiarize the clinician with CA-MRSA as cause of community acquired pneumonia, review the epidemiological, clinical, microbiological characteristics, in order to minimize delays in the administration of the adequate antimicrobial treatment to improve patients outcomes of this deadly condition.
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Mazo Marcela, E. Stupka John, M. Mortensen Eric, Anzueto Antonio and I. Restrepo Marcos, Community-Associated Methicillin Resistant Staphylococcus aureus Pneumonia (CA-MRSA), Current Respiratory Medicine Reviews 2010; 6 (3) . https://dx.doi.org/10.2174/157339810791526201
DOI https://dx.doi.org/10.2174/157339810791526201 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
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