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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Low Molecular Weight and Oligomeric Chitosans and Their Bioactivities

Author(s): Heng Yin, Yuguang Du and Junzeng Zhang

Volume 9, Issue 16, 2009

Page: [1546 - 1559] Pages: 14

DOI: 10.2174/156802609789909795

Price: $65


Chitosan is one of the most abundant marine-based biopolymers. Low molecular weight and oligomeric chitosans are water-soluble hydrolysates of chitosan. They have been shown to have a wide range of biological activities and industrial applications. In particular, low molecular weight and oligomeric chitosans have been reported to have the health benefits such as immunity regulation, anti-tumor, liver protection, blood lipids lowering, anti-diabetic, antioxidant and anti-obesity. In this paper, the preparation and analytical methods, and bioactivities of these low molecular weight and oligomeric chitosans were reviewed, with the latest progresses introduced and discussed.

Keywords: Low molecular weight chitosan (LMWC), chitosan oligosaccharide (COS), preparation, analytical method, bioactivity

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