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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Novel Amphiphilic Hyperbranched Poly (amine-ester) Copolymers Nanoparticles as Protein Drug Delivery

Author(s): Ming Jiang, Tiewei Wang, Qing Xu and Yan Wu

Volume 9, Issue 11, 2009

Page: [1342 - 1356] Pages: 15

DOI: 10.2174/138955709789878088

Price: $65


Novel amphiphilic protein-loaded hyperbranched poly (amine-ester) copolymers nanoparticles were fabricated by double emulsion (DE) and nanoprecipitation (NP) methods. Encapsulation efficiency (EE) of nanoparticles to Bovine serum albumin (BSA) could reach 97.8% at BSA (0.01g/ml), internal phase volume (0.5ml), copolymer weight (50mg), and PVA concentration (4%, w/v) condition.

Keywords: Hyperbranched poly (amine-ester), poly(lactide), ring-opening polymerization, nanoaprticles, double emulsion (DE) method, nanoprecipitation (NP) method, bovine serum albumin, protein delivery system

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