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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Roles of Laminin-332 and α6β4 Integrin in Tumor Progression

Author(s): Y. Kariya, Y Kariya and J. Gu

Volume 9, Issue 11, 2009

Page: [1284 - 1291] Pages: 8

DOI: 10.2174/138955709789878114

Price: $65


Laminin-332 and α6β4 integrin is major hemidesmosome components in the skin. As many studies have shown that laminin-332 and α6β4 integrin play important roles in tumor progression via activation of phosphatidylinositol-3 kinase signaling, understanding of the molecular mechanisms of them could lead to a new drug for cancer therapy.

Keywords: Laminin-332, α6β4 integrin, basement membrane, extracellular matrix, tumor, cell migration, cell adhesion, ErbB2

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