Generic placeholder image

Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Synthesis and Biological Activity of New Triazole Compounds

Author(s): Hanane Al Bay, Bouchra Quaddouri, Abdelkarim Guaadaoui, Rachid Touzani, Nour-Eddine Benchat, Abdellah Hamal, Mustafa Taleb, Mohammed Bellaoui and Sghir El Kadiri

Volume 7, Issue 1, 2010

Page: [41 - 45] Pages: 5

DOI: 10.2174/157018010789869352

Price: $65


Six new N,N-bis(1,2,4-triazol-1-ylmethyl)amines have been prepared in one step by condensation of 1- (hydroxymethyl)triazole with a series of amines. These reactions were carried out in refluxed CH3CN for 4 hours. The products were recuperated with excellent and good yields (75-89.5%). Compounds (3a-f) were screened for their antifungal activity against the budding yeast Saccharomyces cerevisiae and their antibacterial activity against Escherichia coli.

Keywords: Synthesis, Antifungal activity, Antibacterial activity, Tridentate ligand, Nitrogen-rich and Triazole

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy