The Small GTPase Activity of the ROC Domain from LRRK2, a Parkinsons Disease Related Protein

Qing-Shan      Fu; Ai-Xin      Song; Su-Xia      Li; Hong-Yu      Hu

Abstract

Mutations in the LRRK2 gene have been implicated in the pathogenesis of Parkinsons disease. This work provides biochemical evidence that the ROC domain of LRRK2 functions as a small GTPase, and the Parkinsons disease-associated mutants do not appear to have reduced GTP hydrolysis activities.

Keywords: LRRK2, ROC domain, small GTPase, GTP binding, Parkinson's disease

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