Generic placeholder image

Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

The Small GTPase Activity of the ROC Domain from LRRK2, a Parkinsons Disease Related Protein

Author(s): Qing-Shan Fu, Ai-Xin Song, Su-Xia Li and Hong-Yu Hu

Volume 16, Issue 12, 2009

Page: [1442 - 1446] Pages: 5

DOI: 10.2174/092986609789839386

Price: $65


Mutations in the LRRK2 gene have been implicated in the pathogenesis of Parkinsons disease. This work provides biochemical evidence that the ROC domain of LRRK2 functions as a small GTPase, and the Parkinsons disease-associated mutants do not appear to have reduced GTP hydrolysis activities.

Keywords: LRRK2, ROC domain, small GTPase, GTP binding, Parkinson's disease

Rights & Permissions Print Export Cite as
© 2023 Bentham Science Publishers | Privacy Policy