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Mini-Reviews in Organic Chemistry


ISSN (Print): 1570-193X
ISSN (Online): 1875-6298

Intrinsically Fluorescent Base-Discriminating Nucleoside Analogs

Author(s): D. W. Dodd and R. H.E. Hudson

Volume 6, Issue 4, 2009

Page: [378 - 391] Pages: 14

DOI: 10.2174/157019309789371659

Price: $65


Modified nucleosides possessing intrinsically fluorescent heterocycles as base surrogates that are capable of canonical basepairing are becoming important biomolecular tools. These “base-discriminating fluorophores” (BDFs) find use in hybridization-based mismatch detection, elucidation of DNA damage and the study of localized structural phenomena as exemplified in the study of ribozymes and nucleic acid/ligand interactions. In this review, an historical perspective will be given along with some of the more recent highlights in this rapidly developing field.

Keywords: Base-discriminating fluorophore, SNP, DNA, luminescence, solvatochromatism

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