Abstract
Modified nucleosides possessing intrinsically fluorescent heterocycles as base surrogates that are capable of canonical basepairing are becoming important biomolecular tools. These “base-discriminating fluorophores” (BDFs) find use in hybridization-based mismatch detection, elucidation of DNA damage and the study of localized structural phenomena as exemplified in the study of ribozymes and nucleic acid/ligand interactions. In this review, an historical perspective will be given along with some of the more recent highlights in this rapidly developing field.
Keywords: Base-discriminating fluorophore, SNP, DNA, luminescence, solvatochromatism
Mini-Reviews in Organic Chemistry
Title: Intrinsically Fluorescent Base-Discriminating Nucleoside Analogs
Volume: 6 Issue: 4
Author(s): D. W. Dodd and R. H.E. Hudson
Affiliation:
Keywords: Base-discriminating fluorophore, SNP, DNA, luminescence, solvatochromatism
Abstract: Modified nucleosides possessing intrinsically fluorescent heterocycles as base surrogates that are capable of canonical basepairing are becoming important biomolecular tools. These “base-discriminating fluorophores” (BDFs) find use in hybridization-based mismatch detection, elucidation of DNA damage and the study of localized structural phenomena as exemplified in the study of ribozymes and nucleic acid/ligand interactions. In this review, an historical perspective will be given along with some of the more recent highlights in this rapidly developing field.
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Cite this article as:
Dodd W. D. and Hudson H.E. R., Intrinsically Fluorescent Base-Discriminating Nucleoside Analogs, Mini-Reviews in Organic Chemistry 2009; 6 (4) . https://dx.doi.org/10.2174/157019309789371659
DOI https://dx.doi.org/10.2174/157019309789371659 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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