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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Quantitative Prediction of Critical Amino Acid Positions for Protein Folding

Author(s): Trias Thireou, Vassilios Atlamazoglou, Nikolaos A. Papandreou, Mathieu Lonquety, Jacques Chomilier and Elias Eliopoulos

Volume 16, Issue 11, 2009

Page: [1342 - 1349] Pages: 8

DOI: 10.2174/092986609789353673

Price: $65


The MIR algorithm provides an ab initio prediction of a proteins core residues. An improved version, the MIR2, is presented and validated on 3203 proteins from PDB. Structures are decomposed in Closed Loops, their limits constituting the observed core residues. They are predicted by MIR2 with an accuracy approaching 80%.

Keywords: Protein folding, monte carlo method, lattice simulation, folding nucleus, hydrophobic core

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