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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Synthesis and Characterization of Substituted Ethyl 2-(1-aminocyclobutyl)- 5-(benzoyloxy)-6-hydroxypyrimidine-4-carboxylate Derivatives as Antioxidant Agents

Author(s): D. Asha, Manish Malviya, S. Chandrappa, C. T. Sadashiva, K. Vinaya, D. S. Prasanna and K. S. Rangappa

Volume 6, Issue 8, 2009

Page: [637 - 643] Pages: 7

DOI: 10.2174/157018009789353509

Price: $65

Abstract

A series of novel ethyl 2-(1-aminocyclobutyl)-5-(benzoyloxy)-6-hydroxy-pyrimidine-4-carboxylate derivatives 8(a-i) were synthesized by nucleophilic substitution reaction of ethyl 2-(1-aminocyclobutyl)-5-(benzoyloxy)-6-hydroxypyrimidine- 4-carboxylate (7) with different substituted aliphatic/aromatic sulfonyl chlorides (R-SO2-Cl). All the synthesized compounds were characterized by IR, 1H NMR and LC/MS analysis. The synthesized compounds were evaluated for their antioxidant activity by diphenylpicrylhydrazyl (DPPH) assay and also by hydroxy radical induced DNA strand scission assay. Among the synthesized compounds 8c, 8f and 8i showed promising antioxidant activity.

Keywords: Benzyl 1-cyanocyclobutylcarbamate, Pyrimidine, Hydroxy radical, DPPH Assay, Antioxidant

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