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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Structure-Based Drug Design Strategies in Medicinal Chemistry

Author(s): Adriano D. Andricopulo, Lívia B. Salum and Donald J. Abraham

Volume 9, Issue 9, 2009

Page: [771 - 790] Pages: 20

DOI: 10.2174/156802609789207127

Price: $65


A broad variety of medicinal chemistry approaches can be used for the identification of hits, generation of leads, as well as to accelerate the development of high quality drug candidates. Structure-based drug design (SBDD) methods are becoming increasingly powerful, versatile and more widely used. This review summarizes current developments in structure-based virtual screening and receptor-based pharmacophores, highlighting achievements as well as challenges, along with the value of structure-based lead optimization, with emphasis on recent examples of successful applications for the identification of novel active compounds.

Keywords: Structure-based drug design, medicinal chemistry, virtual screening, QSAR, pharmacophores

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