Abstract
The waning effectiveness of established tuberculosis treatments due to the rise of multi and extensively drugresistant strains of Mycobacterium tuberculosis, coupled with the synergism of HIV infection, demands basic research efforts to inform focused drug development programs. Structural genomics projects provide rich sources of information for the rational design of anti-tubercular drugs, aiming to exploit unique and novel protein features and interactions based on atomic resolution structures. This review compiles structures of M. tuberculosis proteins elucidated since January 2007 that are promising avenues for drug design, encompassing proteins involved with known and experimental antituberculosis drugs, metabolism, dealing with the hostile environment of the host organism, and information processing.
Keywords: Tuberculosis, Mycobacterium tuberculosis, structural genomics, protein drug targets, X-ray crystallography
Infectious Disorders - Drug Targets
Title: Advances in Mycobacterium tuberculosis Structural Genomics: Investigating Potential Chinks in the Armor of a Deadly Pathogen
Volume: 9 Issue: 5
Author(s): N. Chim, L. M. McMath, M. Beeby and C. W. Goulding
Affiliation:
Keywords: Tuberculosis, Mycobacterium tuberculosis, structural genomics, protein drug targets, X-ray crystallography
Abstract: The waning effectiveness of established tuberculosis treatments due to the rise of multi and extensively drugresistant strains of Mycobacterium tuberculosis, coupled with the synergism of HIV infection, demands basic research efforts to inform focused drug development programs. Structural genomics projects provide rich sources of information for the rational design of anti-tubercular drugs, aiming to exploit unique and novel protein features and interactions based on atomic resolution structures. This review compiles structures of M. tuberculosis proteins elucidated since January 2007 that are promising avenues for drug design, encompassing proteins involved with known and experimental antituberculosis drugs, metabolism, dealing with the hostile environment of the host organism, and information processing.
Export Options
About this article
Cite this article as:
Chim N., McMath M. L., Beeby M. and Goulding W. C., Advances in Mycobacterium tuberculosis Structural Genomics: Investigating Potential Chinks in the Armor of a Deadly Pathogen, Infectious Disorders - Drug Targets 2009; 9 (5) . https://dx.doi.org/10.2174/187152609789105731
DOI https://dx.doi.org/10.2174/187152609789105731 |
Print ISSN 1871-5265 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3989 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Nanoparticle as An Emerging Tool in Pulmonary Drug Delivery System
Micro and Nanosystems Drugs that Inhibit Mycolic Acid Biosynthesis in Mycobacterium tuberculosis - An Update
Medicinal Chemistry Reviews - Online (Discontinued) Mode Action Prediction of Butein as Antibacterial Oral Pathogen against <i>Enterococcus faecalis</i> ATCC 29212 and an Inhibitor of MurA Enzyme: In Vitro and In Silico Study
Letters in Drug Design & Discovery Recent Developments in Drug Design of NO-donor Hybrid Compounds
Mini-Reviews in Medicinal Chemistry New Developments in Antimicrobial Use in Sepsis
Current Pharmaceutical Design A New Catalytic Method for Eco-Friendly Synthesis of Quinoxalines by Zirconium (IV) Oxide Chloride Octahydrate Under Mild Conditions
Letters in Organic Chemistry Toll-Like Receptors, Cytokines and the Immunotherapeutics of Asthma
Current Pharmaceutical Design A Comprehensive Review on Phytochemistry and Pharmacological Effects of Stinging Nettle (Urtica dioica)
Current Traditional Medicine Vitamin D and Infectious Diseases
Endocrine, Metabolic & Immune Disorders - Drug Targets Predictors of Response to TNF Antagonists
Current Pharmaceutical Design Recent Advances of Fluorescent Technologies for Drug Discovery and Development
Current Pharmaceutical Design Vesicular Carriers for Skin Drug Delivery: The Pheroid™ Technology
Current Pharmaceutical Design Sulfated Oligosaccharides: New Targets for Drug Development?
Current Medicinal Chemistry Synthesis and Structural Elucidation of Novel Benzothiazole Derivatives as Anti-tubercular Agents: In-silico Screening for Possible Target Identification
Medicinal Chemistry Advancements in Devices and Particle Engineering in Dry Powder Inhalation Technology
Current Topics in Medicinal Chemistry Nanomedicines as Drug Delivery Carriers of Anti-Tubercular Drugs: From Pathogenesis to Infection Control
Current Drug Delivery Editorial (Thematic Issue: Searching a New Antibiotic Prototype: Snake Venoms)
Mini-Reviews in Organic Chemistry Synthetic Methods Applied in the Preparation of Coumarin-based Compounds
Current Organic Chemistry Development of Antibacterial Drugs by Targeting Toll-Like Receptors
Current Topics in Medicinal Chemistry Insights into Angiogenesis in Non-Small Cell Lung Cancer: Molecular Mechanisms, Polymorphic Genes, and Targeted Therapies
Recent Patents on Anti-Cancer Drug Discovery